Whitening Efficacy and Tolerability of GuruNanda® Oil Pulling Oral Rinse
A Randomized, Double-Blind, Placebo-Controlled Clinical Study
Objective
The primary objective of this clinical study was to evaluate the tooth whitening efficacy of GuruNanda® Oil Pulling (Coco-Mint) Oral Rinse compared with a placebo control in adult subjects presenting with baseline tooth shades of A2 or darker. Secondary objectives included assessment of product tolerability, user compliance, and overall satisfaction following daily use over a four-week period.
The oral rinse formulation contains medium-chain triglycerides (MCT) and a proprietary essential oil blend including peppermint, spearmint, clove, cardamom, fennel, tea tree, and oregano, designed to support oral hygiene and aesthetic whitening through gentle mechanical and biochemical cleansing mechanisms.
Process
This single-center, randomized, double-blind, placebo-controlled clinical study enrolled 100 adult participants who met predefined inclusion and exclusion criteria to minimize bias. Subjects were randomized equally into two groups:
- Active Group (A): GuruNanda® Oil Pulling (Coco-Mint) Oral Rinse
- Placebo Group (C): Mouthwash without active oil components
Participants self-administered 10 mL of the assigned rinse once daily in the morning before tooth brushing for a duration of four weeks. Clinical assessments were conducted at baseline (screening), Week 2, and Week 4.
The primary efficacy endpoint was change in tooth shade measured using the VITA shade scale. Secondary endpoints included compliance, tolerability ratings, and subject-reported satisfaction. Safety evaluations comprised oral examinations, physical assessments, vital signs, and laboratory investigations including hematology and biochemistry. Statistical analysis was performed using the Wilcoxon test, with statistical significance defined as p < 0.05.
Results
Table 1. Mean Tooth Whiteness (VITA Shade Scale) Across Study Visits
| Visit | Active Group (A) Mean ± SD |
Placebo Group (C) Mean ± SD |
|---|---|---|
| Screening | 5.99 ± 2.63 | 6.16 ± 2.42 |
| Week 2 | 6.97 ± 2.77 | 6.16 ± 2.42 |
| Week 4 | 7.29 ± 2.83 | 6.22 ± 2.46 |
| p-Value (A vs C) | < 0.0001 | |
Figure 1. Comparative changes in mean tooth whiteness (VITA shade scale) at screening, Week 2, and Week 4 visits. The active oil pulling rinse demonstrated statistically significant whitening improvement compared with placebo.Table 2. Treatment Compliance and Tolerability
| Parameter | Active Group (A) | Placebo Group (C) |
|---|---|---|
| Compliance (Mean ± SD) | 100.00 ± 0.00 | 100.00 ± 0.00 |
| Tolerability – Excellent (%) | 92.0 | 90.0 |
| Tolerability – Good (%) | 8.0 | 10.0 |
| Adverse Events | None | None |
Observation
GuruNanda® Oil Pulling (Coco-Mint) Oral Rinse demonstrated statistically significant tooth whitening effects as early as Week 2, with continued improvement observed through Week 4. The active group exhibited a consistent upward shift toward lighter VITA shade values, while the placebo group showed minimal change. The product was well tolerated, with no reported adverse events, oral irritation, or sensitivity.
High compliance and favorable tolerability ratings indicate strong user acceptance, supported by positive sensory experience and ease of daily use.
Conclusion
This randomized, double-blind clinical evaluation confirms that GuruNanda® Oil Pulling (Coco-Mint) Oral Rinse provides effective and statistically significant tooth whitening in adults with A2 or darker baseline shades. The formulation offers a safe, non-peroxide whitening alternative that improves dental aesthetics while maintaining excellent tolerability.
These findings support its use as a gentle, natural, and consumer-friendly whitening solution suitable for daily oral care regimens.